290s - Kings Ptolemaic Dynasty 304-030 304- 284 Ptolemy I Soter I

298-290: 3rd Samnite War creates coalition of Samnites, Etruscans, Celts, Sabines, Lucanians, Umbrians in opposition to Rome and her allies

297: Casander dies.

280s - Kings 304- 284 Ptolemy I Soter I 285-246 Ptolemy II

287: Hortensian Law makes Plebiscites of the Roman plebian assembly (comitia tributa) binding without the ratification of the Senate or the Centuriate Assembly.
283: Ptolemy dies.
282: Messina falls to Mamertine mercenaries.
281: Seleucus defeats and kills Lysimachus (age 80), in the plain of Coron, near Ipsus.

270s - Kings 285-46 Ptolemy II
279: Vict of Pyrhus at Ausculum with great losses (Pyrrhic victory) Plutarch's Pyrrhus
278: Celts (or Gauls) invade Macedonia and Thrace.
277: Antigonus Gonatus (grandson of Antipater) defeats Celts at Lysimacheia .
275 Romans defeat Pyrrhus at Beneventum
Livy's The History of Rome

260s - Kings 285-46 Ptolemy II
264: Start of the First Punic War to 241. (Carthage vs. Rome)
260: Roman ships defeat Carthaginian ships at Mylae.

250s - Kings 285-46 Ptolemy II
256: Roman ships defeat Carthaginian ships at Cape Ecnomus.

240s Kings 285-46 Ptolemy II 246-21 Ptolemy III Euergetes I
243: Aratus captures Corinth.
241: Roman ships defeat Carthaginian ships off the Aegadian Isles. First Punic War ends.

230s Kings 246-21 Ptolemy III Euergetes I
239: Antigonius dies of old age.
235: Attalus I defeats the Galatians.

220s  Kings 246-21 Ptolemy III Euergetes I 221-05 Ptolemy IV Philopator
227: Earthquake nearly destroys Rhodes.

210s Kings 221-05 Ptolemy IV Philopator 205-180 Ptolemy V Epiphanes king2
219: Hannibal captures Saguntum in Spain.
218: Declaration of Second Punic War to 201 (Carthage vs.Rome)
217: Hannibal crosses Alps from Gaul into Italy.
216: Hannibal defeats Roman army at Cannae (worst Rom def in history, 50,000 out of 86,000 men lost).
214: Roman General Marcus Claudius Marcellus besieges Syracuse, which is allied with Carthage. War machines designed by Greek mathematician Archimedes devastate Roman war ships. The siege fails and the blockade begins.
212: Marcellus attacks Syracuse and gains the city. He gives his soldiers one day's leave to loot the city. A Roman soldier runs Archimedes through with a sword.

200s Kings 221-05 Ptolemy IV Philopator 205-180 Ptolemy V Epiphanes
202: Hannibal defeated at Zama by Scipio Africanus